ORIGINAL PAPER
Carotid intima-media thickness and inflammatory biomarkers in adolescents with tension-type headache
1
Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poznan, Poland
2
Department of Paediatric Radiology, Poznan University of Medical Sciences, Poznan, Poland
Submission date: 2019-09-10
Final revision date: 2019-11-11
Acceptance date: 2019-11-11
Publication date: 2019-11-19
Pediatr Pol 2019;94(5):283-287
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Primary headaches are frequent complaints among adolescents. Tension-type headache (TTH), which causes symptoms influencing the patients’ quality of life, can be associated with various medical disorders.
Aim of the study:
To research the reason for TTH in adolescents.
Material and methods:
The study included 76 patients, aged from 14 to 17 years, diagnosed due to TTH. Patients with the carotid intima-media thickness (cIMT) in the 90th percentile (the cut-off point: 0.42 mm for boys, and 0.41 mm for girls) were included in group 1, and the rest in group 2. All the patients underwent laboratory tests with serum levels of IL-6, IL-10, TNF-α, and sICAM-1. Twenty-six (34%) patients were enrolled in group 1 and 50 (66%) in group 2.
Results:
There were no significant differences in age, sex, height, BMI, and systolic and diastolic blood pressure between patients from both studied groups. The mean cIMT value (mean, SD) for all patients from the study group was 0.41 ±0.012 mm: for girls 0.39 ±0.014 mm and for boys 0.44 ±0.016 mm. In 16-year-old adolescents, the cIMT was significantly higher in boys than girls. In 17-year-old patients, cIMT was significantly higher in boys only in group 1. The significantly higher concentrations of IL-6, TNF-α, and sICAM-1 were found in patients from group 1. Whereas the IL-10 level was significantly higher in the control group. In over one-third of patients (34%) with TTH, the cIMT was in the 90th percentile, despite having normal BMI, blood pressure, and lipid profile in serum.
Conclusions:
The inflammatory process in the vascular wall could be considered as the reason for the higher cIMT value and/or TTH in adolescents.
Primary headaches are frequent complaints among adolescents. Tension-type headache (TTH), which causes symptoms influencing the patients’ quality of life, can be associated with various medical disorders.
Aim of the study:
To research the reason for TTH in adolescents.
Material and methods:
The study included 76 patients, aged from 14 to 17 years, diagnosed due to TTH. Patients with the carotid intima-media thickness (cIMT) in the 90th percentile (the cut-off point: 0.42 mm for boys, and 0.41 mm for girls) were included in group 1, and the rest in group 2. All the patients underwent laboratory tests with serum levels of IL-6, IL-10, TNF-α, and sICAM-1. Twenty-six (34%) patients were enrolled in group 1 and 50 (66%) in group 2.
Results:
There were no significant differences in age, sex, height, BMI, and systolic and diastolic blood pressure between patients from both studied groups. The mean cIMT value (mean, SD) for all patients from the study group was 0.41 ±0.012 mm: for girls 0.39 ±0.014 mm and for boys 0.44 ±0.016 mm. In 16-year-old adolescents, the cIMT was significantly higher in boys than girls. In 17-year-old patients, cIMT was significantly higher in boys only in group 1. The significantly higher concentrations of IL-6, TNF-α, and sICAM-1 were found in patients from group 1. Whereas the IL-10 level was significantly higher in the control group. In over one-third of patients (34%) with TTH, the cIMT was in the 90th percentile, despite having normal BMI, blood pressure, and lipid profile in serum.
Conclusions:
The inflammatory process in the vascular wall could be considered as the reason for the higher cIMT value and/or TTH in adolescents.
REFERENCES (23)
1.
Özge A, Bugdayci R, Sasmaz T, et al. The sensitivity and specificity of the case definition criteria in the diagnosis of a headache: a school-based epidemiological study of 5562 children in Mersin. Cephalalgia 2002; 22: 791-798.
2.
Sillanpaa M, Piekkala P. Prevalence of migraine and other headaches in early puberty. Scand J Prim Health Care 1984; 2: 27-32.
3.
Guidetti V, Lucchese F, Bellini B. Is the migraines female brain different? Some new evidence. Brain 2012; 135: 2311-2313.
4.
Anttila P, Metsähonkala L, Aromaa M, et al. Determinants of a tension-type headache in children. Cephalalgia 2002; 22: 401-408.
5.
Dyb G, Stensland S, Zwart JA. Psychiatric comorbidity in a childhood and adolescent headache. Curr Pain Headache Rep 2015; 19: 5.
6.
Bellini B, Arruda M, Cescut A, et al. Headache and comorbidity in children and adolescents. J Headache Pain 2013, 14: 79.
7.
Olson M, Chambers M, Shaibi G. Pediatric Markers of Adult Cardiovascular Disease. Curr Pediatr Rev 2017; 13: 255-259.
8.
Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 2006; 86: 515-581.
9.
Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis 2012; 34: 290-296.
10.
Doyon A, Kracht D, Bayazit AK, et al. Carotid Artery Intima-Media Thickness and Distensibility in Children and Adolescents. Hypertension 2013; 62: 550-556.
11.
Engelen L, Ferreira I, Stehouwer CD, et al. Collaboration RV for AM. Reference intervals for common carotid intima-media thickness measured with echo-tracking: relation with risk factors. Eur Heart J 2012; 34: 2368-2380.
12.
Den Ruijter HM, Peters SA, Anderson TJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA 2012; 308: 796-803.
13.
Spence JD. Carotid ultrasound phenotypes are biologically distinct. Arterioscler Thromb Vasc Biol 2015; 35: 1910-1913.
14.
Pollex RL, Spence JD, House AA, et al. A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes. Cardiovasc Ultrasound 2005; 3: 15.
15.
Pollex RL, Hegele R. Genetic determinations of carotid ultrasound traits. Curr Atheroscler Rep 2006; 8: 2006-2015.
16.
Tołwińska J, Głowińska B, Urban M, Pieciukiewicz B. Ultrasonographic evaluation of atherosclerotic changes in carotid and brachial arteries in obese and hypertensive children. Przegl Lek 2005; 62: 1346-1351.
17.
Beauloye V, Zech F, Tran HTM, et al. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007; 92: 3025-3032.
18.
Jourdan C, Wühl E, Litwin M, et al. Normative values for intimamedia thickness and distensibility of large arteries in healthy adolescents. J Hypertens 2005; 23: 1707-1715.
19.
Jones DL, Rodriguez VJ, Alcaide ML, et al. Subclinical Atherosclerosis Among Young and Middle-Aged Adults Using Carotid Intima-Media Thickness Measurements. South Med J 2017; 110: 733-737.
20.
Bohm B, Hartmann K, Buck M, Oberhoffer R. Sex differences of carotid intima-media thickness in healthy children and adolescents. Atherosclerosis 2009; 206: 458-463.
21.
Basir FH, Kocer A, Dikici S, et al. The evaluation of atherosclerosis in migraine patients. Pain Pract 2013; 13: 41-45.
22.
Avci AY, Akkucuk MH, Torun E, et al. Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study. Neurol Sci 2019; 40: 703-711.
23.
Sabri MR, Dehghan B, Yaghini O, et al. Endothelial dysfunction state in migraine headache and neutrally mediated syncope in chldren and young adults. J Res Mes Sci 2015; 20: 771-776.
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