REVIEW PAPER
What do we currently know about urticaria in children?
More details
Hide details
1
Department of Paediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
Submission date: 2021-12-19
Final revision date: 2022-01-18
Acceptance date: 2022-01-29
Publication date: 2022-05-06
Pediatr Pol 2022;97(2):133-139
KEYWORDS
TOPICS
ABSTRACT
Urticaria is a common pediatric dermatosis characterized by local swelling, pruritus, and skin redness. The primary lesions include wheals and/or angioedema. By definition, acute urticaria lasts up to 6 weeks and usually occurs as a single episode in life. Chronic urticaria lasts over 6 weeks and is uncommon.
Urticaria is a heterogenous disease. The development of skin lesions depends on the action of mast cells and other cells of the immune system, and inflammation is common in all forms of urticaria. Autoimmune mechanisms and activation of coagulation and fibrinolysis also play an important role. The etiology usually remains unknown.
Urticaria, especially its chronic form, contributes to a significant decrease in quality of life due to prolonged discomfort and the necessity of long-term and sometimes expensive treatment.
This article presents an up-to-date review of the literature on the incidence, causes, diagnosis, treatment and prognosis of urticaria in children.
REFERENCES (41)
1.
Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy 2022; 77: 734-766.
2.
Nowicki R, Grubska-Suchanek E, Jahnz-Różyk K, et al. Urticaria. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society and the Polish Society of Allergology. Dermatol Rev 2020; 107: 1-14.
3.
Wang EA, Chan SK. Chronic urticaria in children: an update on diagnosis and treatment. Curr Allergy Asthma Rep 2020; 20: 31.
4.
Kudryavtseva AV, Neskorodova KA, Staubach P. Urticaria in children and adolescents: an updated review of the pathogenesis and management. Pediatr Allergy Immunol 2019; 30: 17-24.
5.
Cornillier H, Giraudeau B, Munck S, et al. Chronic spontaneous urticaria in children – a systematic review on interventions and comorbidities. Pediatr Allergy Immunol 2018; 29: 303-310.
6.
Mazur M, Czarnobilska M, Czarnobilska E. Prevalence and potential risk factors of urticaria in the Polish population of children and adolescents. Postepy Dermatol Alergol 2020; 37: 785-789.
7.
Raciborski F, Kłak A, Czarnecka-Operacz M, et al. Epidemiology of urticaria in Poland – nationally representative survey results. Postepy Dermatol Alergol 2018; 35: 67-73.
8.
Comert S, Celebioglu E, Karakaya G, et al. The general characteristics of acute urticaria attacks and the factors predictive of progression to chronic urticaria. Allergol Immunopathol (Madr) 2013; 41: 239-245.
9.
Eun SJ, Lee JY, Kim DY, Yoon HS. Natural course of new-onset urticaria: results of a 10-year follow-up, nationwide, population-based study. Allergol Int 2019; 68: 52-58.
10.
Powell RJ, Leech SC, Till S, et al. British Society for Allergy and Clinical Immunology. BSACI guideline for the management of chronic urticaria and angioedema. Clin Exp Allergy 2015; 45: 547-565.
11.
Antia C, Baquerizo K, Korman A, et al. Urticaria: a comprehensive review: epidemiology, diagnosis, and work-up. J Am Acad Dermatol 2018; 79: 599-614.
12.
Czarnecka-Operacz M, Szulczyńska-Gabor J, Leśniewska K, et al. Acute-phase response and its biomarkers in acute and chronic urticaria. Postepy Dermatol Alergol 2018; 35: 400-407.
13.
Giménez-Arnau AM, DeMontojoye L, Asero R, et al. The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells. J Allergy Clin Immunol Pract 2021; 9: 2195-2208.
14.
Papadopoulos J, Karpouzis A, Tentes J, et al. Assessment of interleukins IL-4, IL-6, IL-8, IL-10 in acute urticaria. J Clin Med Res 2014; 6: 133-137.
15.
Wedi B, Raap U, Wieczorek D, et al. Urticaria and infections. Allergy Asthma Clin Immunol 2009; 5: 10.
16.
Machura E, Jońska-Golus M, Krakowczyk H, et al. Etiologia i przebieg kliniczny pokrzywki u hospitalizowanych dzieci [Etiology and clinical course of urticaria in hospitalized children]. Med Wieku Rozwoj 2013; 17: 64-71.
17.
Zaryczański J, Ochab A, Ochab M, et al. D-dimer concentrations in acute urticaria in children. Allergol Immunopathol 2021; 49: 107-112.
18.
Daneshgaran G, Dubin DP, Gould DJ. Cutaneous manifestations of COVID-19: an evidence-based review. Am J Clin Dermatol 2020; 21: 627-639.
19.
Liu TH, Lin YR, Yang KC, et al. First attack of acute urticaria in pediatric emergency department. Pediatr Neonatol 2008; 49: 58-64.
20.
Moolani Y, Lynde C, Sussman G. Advances in understanding and managing chronic urticaria. F1000Res 2016; 16: 5.
21.
Caffarelli C, Paravati F, El Hachem, et al. Management of chronic urticaria in children: a clinical guideline. Ital J Pediatr 2019; 45: 101.
22.
Ertam I, Biyikli SE, Yazkan FA, et al. The frequency of nasal carriage in chronic urticaria patients. J Eur Acad Dermatol Venereol 2007; 21: 777-780.
23.
Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clin Exp Allergy 2009; 39: 777-787.
24.
Bracken SJ, Abraham S, MacLeod AS. Autoimmune theories of chronic spontaneous urticaria. Front Immunol 2019; 10: 627.
25.
AlBalbeesi A, Alsalman H, Alotaibi H, et al. Prevalence of Helicobacter pylori infection among rosacea and chronic spontaneous urticaria patients in a tertiary hospital in Riyadh, Saudi Arabia. Cureus 2021; 13: e17617.
26.
Kolkhir P, Balakirski G, Merk HF, et al. Chronic spontaneous urticaria and internal parasites – a systematic review. Allergy 2016; 71: 308-322.
27.
Heinzerling L, Mari A, Bergmann KC, et al. The skin prick test – European standards. Clin Transl Allergy 2013; 3: 3.
28.
Nazar W, Plata-Nazar K, Sznurkowska K, et al. Histamine intolerance in children: a narrative review. Nutrients 2021; 13: 1486.
29.
Wagner N, Dirk D, Peveling-Oberhag A, et al. A popular myth – low-histamine diet improves chronic spontaneous urticaria – fact or fiction? J Eur Acad Dermatol Venereol 2017; 31: 650-655.
30.
Ben-Shoshan M, Grattan CE. Management of pediatric urticaria with review of the literature on chronic spontaneous urticaria in children. J Allergy Clin Immunol Pract 2018; 6: 1152-1161.
31.
Grzanka R, Damasiewicz-Bodzek A, Kasperska-Zajac A. Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria. Allergy Asthma Clin Immunol 2018; 14: 27.
32.
Li Y, Wang W, Yang F, et al. The regulatory roles of neutrophils in adaptive immunity. Cell Commun Signal 2019; 17: 147.
33.
Zhang Y, Zhang H, Du S, et al. Advanced biomarkers: therapeutic and diagnostic targets in urticaria. Int Arch Allergy Immunol 2021; 182: 917-931.
34.
Can PK, Etikan P, Kızıltaç U, et al. Fric test revisited: a suggestion for a new scoring system and its correlation with Urticaria Control Test and Dermatology Life Quality Index. Int Arch Allergy Immunol 2019; 178: 76-82.
35.
Sarti L, Barni S, Giovannini M, et al. Efficacy and tolerability of the updosing of second-generation non-sedating H1 antihistamines in children with chronic spontaneous urticaria. Pediatr Allergy Immunol 2021; 32: 153-160.
36.
Papadopoulos NG, Zuberbier T. The safety and tolerability profile of bilastine for chronic urticaria in children. Clin Transl Allergy 2019; 9: 55.
37.
Tsabouri S, Arasi S, Beken B, et al. A European survey of management approaches in chronic urticaria in children: EAACI pediatric urticaria taskforce. Pediatr Allergy Immunol 2022; 33: e13674.
38.
Chang J, Cattelan L, Ben-Shoshan M, et al. Management of pediatric chronic spontaneous urticaria: a review of current evidence and guidelines. J Asthma Allergy 2021; 14: 187-199.
39.
Fox CW, Khaw CL, Gerke AK, Lund BC. Montelukast and neuropsychiatric events – a sequence symmetry analysis. J Asthma 2022: 1-7.
40.
Huang PY, Yang YH, Huang YH, et al. Montelukast does not increase the risk of attention-deficit/hyperactivity disorder in pediatric asthma patients: a nationwide population-based matched cohort study. J Formos Med Assoc 2021; 120: 1369-1376.
41.
Cortellazzo Wiel L, Conversano E, Giangreco M, et al. Natural history and predictors of recovery in children with chronic spontaneous urticaria. Pediatr Allergy Immunol 2021; 32: 201-204.