CASE REPORT
Nonalcoholic fatty pancreas disease in obese children: case reports
More details
Hide details
1
Department of Paediatrics, Gastroenterology, Hepatology, Nutrition, and Allergology, Medical University of Bialystok, Bialystok, Poland
Submission date: 2019-03-07
Final revision date: 2019-04-04
Acceptance date: 2019-04-06
Publication date: 2019-06-28
Pediatr Pol 2019;94(3):210-213
KEYWORDS
TOPICS
ABSTRACT
Nonalcoholic fatty pancreas disease (NAFPD) is defined as excessive lipid accumulation in the pancreas, which occurs in obese patients. Similarly to nonalcoholic fatty liver disease (NAFLD), it can progress towards more advanced stage – nonalcoholic steatopancreatitis (NASP). However, the epidemiology, pathogenesis, including its relation to metabolic syndrome (MetS), and treatment recommendations have not been fully established yet. The aim of our study was to present three cases of NAFPD in obese children. We present their examination, diagnostic process, laboratory and imaging study results to note that not only NAFLD but also NAFPD can coexist with childhood obesity.
REFERENCES (18)
1.
Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766-781.
2.
Kułaga Z, Grajda A, Gurzkowska B, et al. The prevalence of overweight and obesity among Polish school- aged children and adolescents. Przegl Epidemiol 2016; 70: 641-651.
3.
Friend A, Craig L, Turner S. The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord 2013; 11: 71-80.
4.
Della Corte C, Ferrari F, Villani A, et al. Epidemiology and Natural History of NAFLD. J Med Biochem 2015; 34: 13-17.
5.
Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016; 64: 73-84.
6.
Ogilvie RF. The island of Langerhans in 19 cases of obesity. J Pathol Bac 1933; 37: 473-481.
7.
Olsen TS. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol Microbiol Scand A 1978; 86A: 367-373.
8.
Smits MM, van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol 2011; 8: 169-177.
9.
Pham YH, Bingham BA, Bell CS, et al. Prevalence of Pancreatic Steatosis at a Pediatric Tertiary Care Center. South Med J 2016; 109: 196-198.
10.
Al-Haddad M, Khashab M, Zyromski N, et al. Risk factors for hyperechogenic pancreas on endoscopic ultrasound: a case-control study. Pancreas 2009; 38: 672-675.
11.
van Geenen EJ, Smits MM, Schreuder TC, et al. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas 2010; 39: 1185-1190.
12.
Della Corte C, Mosca A, Majo F, et al. Nonalcoholic fatty pancreas disease and Nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol (Oxf) 2015; 83: 656-662.
13.
Yu TY, Wang CY. Impact of non-alcoholic fatty pancreas disease on glucose metabolism. J Diabetes Investig 2017; 8: 735-747.
14.
Singh RG, Yoon HD, Wu LM, et al. Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression. Metabolism 2017; 69: 1-13.
15.
Romana BS, Chela H, Dailey FE, et al. Non-Alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the Fifth Component of Metabolic Syndrome? A Literature Review. Endocr Metab Immune Disord Drug Targets 2018; 18: 547-554.
16.
Singh RG, Yoon HD, Poppitt SD, et al. Ectopic fat accumulation in the pancreas and its biomarkers: A systematic review and meta-analysis. Diabetes Metab Res Rev 2017; 33: e2918.
17.
Li S, Su L, Lv G, et al. Transabdominal ultrasonography of the pancreas is superior to that of the liver for detection of ectopic fat deposits resulting from metabolic syndrome. Medicine (Baltimore) 2017; 96: e8060.
18.
Khoury T, Asombang AW, Berzin TM, et al. The Clinical Implications of Fatty Pancreas: A Concise Review. Dig Dis Sci 2017; 62: 2658-2667.