ORIGINAL PAPER
Frequency of contact allergy to house dust mites in children with atopic dermatitis
1
Pediatric, Allergology and Cardiology Ward, Provincial Hospital in Torun, Torun, Poland
2
Department of Pediatric, Allergology and Gastroentrology, Nicolaus Copernicus Univeristy, Collegium Medicum, Bydgoszcz, Poland
3
University Hospital No 1 in Bydgoszcz, Poland
Submission date: 2022-01-05
Final revision date: 2022-03-20
Acceptance date: 2022-03-29
Publication date: 2022-06-10
Pediatr Pol 2022;97(2):118-124
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Frequency of contact allergy to house dust mites (HDM) in children with atopic dermatitis (AD) in terms of selected demographic factors: age, gender, and place of residence, showing the relationship between the severity of AD and the coexistence of contact allergy to HDM
Material and methods:
Patients were divided into 3 groups. The study involved 85 children with AD up to the age of 5 years, in whom no elevated total IgE concentration was found and HDM IgE allergy was excluded. Comparative group I consisted of healthy children in the same age group, without a history of atopy (n = 25). Comparative group II included children with AD up to age of 5 years who had an elevated concentration of tot. IgE and/or sIgE against HDM (n = 37)
Results:
Contact allergy to HDM was significantly more frequent in the study group than in comparative group I (p < 0.05). Contact allergy to HDM was more frequent in patients from the comparative group than in the study group. However, the difference did not turn out to be statistically significant (p > 0.05). Contact allergy to HDM was significantly more frequent in comparative group II than in group I. The difference was statistically significant (p < 0.01). The frequency of contact allergy to HDM in children does not depend on selected demographic factors such as sex, age, and place of residence. A statistically significant correlation was found between the occurrence of contact allergy to HDM and the severity of the disease assessed using the SCORAD scale. This relationship was found both in the study group and in the second comparative group.
Conclusions:
Contact allergy to HDM in children with atopic dermatitis affects the severity of the disease. Patch tests with HDM should be recommended in all children with AD.
Frequency of contact allergy to house dust mites (HDM) in children with atopic dermatitis (AD) in terms of selected demographic factors: age, gender, and place of residence, showing the relationship between the severity of AD and the coexistence of contact allergy to HDM
Material and methods:
Patients were divided into 3 groups. The study involved 85 children with AD up to the age of 5 years, in whom no elevated total IgE concentration was found and HDM IgE allergy was excluded. Comparative group I consisted of healthy children in the same age group, without a history of atopy (n = 25). Comparative group II included children with AD up to age of 5 years who had an elevated concentration of tot. IgE and/or sIgE against HDM (n = 37)
Results:
Contact allergy to HDM was significantly more frequent in the study group than in comparative group I (p < 0.05). Contact allergy to HDM was more frequent in patients from the comparative group than in the study group. However, the difference did not turn out to be statistically significant (p > 0.05). Contact allergy to HDM was significantly more frequent in comparative group II than in group I. The difference was statistically significant (p < 0.01). The frequency of contact allergy to HDM in children does not depend on selected demographic factors such as sex, age, and place of residence. A statistically significant correlation was found between the occurrence of contact allergy to HDM and the severity of the disease assessed using the SCORAD scale. This relationship was found both in the study group and in the second comparative group.
Conclusions:
Contact allergy to HDM in children with atopic dermatitis affects the severity of the disease. Patch tests with HDM should be recommended in all children with AD.
REFERENCES (48)
1.
Czarnecka-Operacz M, Silny W. Atopowe zapalenie skóry – aktualny stan wiedzy. Post Dermatol Alergol 2002; 3: 152-160.
3.
Williams H, Flohr C. How epidemiology has challenger 3 prevailing concept about atopic dermatitis. J Allergy Clin Immunol 2006; 118: 209-213.
4.
Williams H, Robertson C, Steward A, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of asthma and allergies in children. J Allergy Clin Immunol 1999; 103: 125-129.
5.
Asher MI, Montefort S, Bjorksten B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry crosssectional surveys. Lancet 2006; 368: 733-743.
6.
Małolepszy J, Liebhart J, Wojtyniak B, Pisiewicz K, Płusa T. Występowanie chorób alergicznych w Polsce. Alergia Astma Immunologia, VII Zjazd PTA, Łódź 2000; S2: 163-169.
7.
Kurzawa R. Atopowe zapalenie skóry. Poradnik dla lekarzy. Helpmed, Kraków 2007, 24-32.
8.
Cork MJ, Danby SG, Vasilopoulos Y, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 2009; 129: 1892-1908.
9.
Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol 2008; 17: 1063-1672.
10.
Proksch E, Folster-Holst R, Jensen JM. Skin barier function, epidermalproliferation and differtiation in egzema. J Dermatol Sci 2006; 43: 159-169.
11.
Novak N, Bieber T, Leung D. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 2003; 112: 128-139.
12.
Davidson WF, Leung DYM, Beck LA, et al. Report from the National Institute of Allergy and Infectious Diseases workshop on “Atopic dermatitis and the atopic march: mechanisms and interventions”. J Allergy Clin Immunol 2019; 143: 894-913.
13.
Silny W, Czarnecka-Operacz M, Gliñski W, Samochocki Z, Jenerowicz D. Atopic dermatitis – contemporary view on pathomechanism and management. Position statement of the Polish Dermatological Society specialists. PDiA 2010; 5: 365–383.
14.
Gliński W, Kruszewski J, Silny W, et al. Postępowanie diagnostyczno-profilaktyczno-lecznicze w atopowym zapaleniu skóry. Konsensus grupy roboczej specjalistów krajowych ds. dermatologii i wenerologii oraz alergologii. Pol Merkur Lek 2004.
15.
Simpson CL, Patel DM, Green KJ. Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol 2011; 12: 565-580.
16.
Seidenari S, Giusti G. Objective assessment of the skin of children affected by atopic by atopic dermatitis: a study pH capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venerol 1995; 75: 429-433.
17.
Hoeger PH, Enzmann CC. Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol 2002; 19: 256-262.
18.
Stamatas GN, Nikolovski J, Luedtke MA, Kollias N, Wiegand BC. Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level. Pediatr Dermatol 2010; 27: 125-131.
19.
Ruiz-Maldano R, Parish LC, Beare JM, Capucci P, Battini ML. The normal skin from birth to adolescence. Textbooks of Pediatric Dermatology. Grune and Starton, Philadelpia 1989, 7-20.
20.
Nikolovski J, Stamatas G, Kollias N, Wiegad B. Infant skin bariermaturation in first year of life. J Am Acad Dermatol 2007; 56: AB153.
21.
Śpiewak R. Alergiczne kontaktowe zapalenie skóry u dzieci. Nowa Med 2001; 8: 23-26.
22.
Wöhrl S, Hemmer W, Focke M, Götz M, Jarisch R. Patch testing in children, adults, and the elderly: influence of age and sex on sensitization patterns. Pediatr Dermatol 2003; 20: 119-123.
23.
Dotterund LK, Falk ES. Contact allergy in relation to hand eczema and atopic diseases in north Norwegian schoolchildren. Acta Paediatrica. 1995; 84: 402-406.
24.
Stoðkutë L, Dubakiene A, Tamodiunas VA. Allergic contact dermatitis and patch testing in children. Acta Medica Lituanica 2005; 12: 71-74.
25.
Roul S, Ducombs G, Taieb A. Usefulness of the European standard series for patch testing in children. Contact Dermatitis 1999; 40: 232-235.
26.
Foti C, Bonifaci E, Casulli C. Contact allergy to topical corticosteroids in children with atopic dermatitis. Contact Dermatitis 2005; 52: 162-163.
27.
Giordano-Labadie F, Lance F, Pellegrin F, et al. Frequency of contact allergy in children with atopic dermatitis: results of a prospective study of 137 cases. Contact Dermatitis 1999; 40: 192-195.
28.
Czarnobilska E, Obtulowicz K, Dyga W, Spiewak R. The most important contact sensitizers in Polish children and adolescents with atopy and chronic recurrent eczema as detected with the extended European Baseline Series. Pediatr Allergy Immunol 2011; 22: 252-256.
29.
De Waard-van der Spek FB, Darsow U, Mortz CG, et al. Oranje EAACI position paper for practical patch testing in allergiccontact dermatitis in children. Pediatr Allergy Immunol 2015; 26: 598-606.
30.
Darsow U, Ring J. Atopy patch testing with aeroallergens and food proteins. In: Contact Dermatitis (Fifth Edition) 2011.
31.
Ingordo V, D’Andria G, D’Andria C, et al. Clinical relevance of contact sensitization in atopic dermatitis. Contact Dermatitis 2001; 45: 239-240.
32.
Benhamou PH, Kalach N, Soulaines P, Donne N, Dupont C. Ready-to-use house dust mites atopy patch test (HDM-Diallertest®), a new screening tool for detection of house dust mites allergy in children. Eur Ann Allergy Clin Immunol 2009; 41: 146-151.
33.
Fuiano N, Fusilli S, Incorvaia C. House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy. Eur J Pediatr 2010; 169: 819-824.
34.
Zhao J, Li LF. Atopy patch test to Dermatophagoides mix in a self-selected population in Beijing. Dermatitis 2013; 24: 82-84.
35.
Souza Lima IPCM, Aarestrup BJ, Souza Lima EM, Souza Lima MC, Souza Lima EC, Aarestrup FM. Brazilian experience with atopy patch tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis 11 Medical and Health Sciences 1107 Immunology. World Allergy Organ J 2018; 11: 27.
36.
Czarnobilska E, ObtułowiczK, Dyga W, et al. Contact hypersensisivity and allergic contact dermatitis among scholl children and teenagers with eczema. Contact Dermatitis 2009; 60: 264-269.
37.
Sharma AD. Allergic contact dermatitis in patient with atopic dermatitis:a clinical study. Indian J Dermatol Venereol Leprol 2005; 71: 96-98.
38.
Belhadjali H, Mohamed M, Youseff M, et al. Contact sensitization in atopic dermatitis :results of peospective study of 89 cases in Tunisia. Contact Dermatitis 2008; 58: 188-189.
39.
Beattie PE, Green C, Lowet G, et al. Which children should we patch test? Clin Exp Dermatol 2007; 32: 6-11.
40.
Mortz CG, Andersen KE. Allergic contact dermatitis in children and adolescents. Contact Dermatitis 1999; 41: 121-130.
41.
Silny W, Czarnecka-Operacz M. Alergeny powietrznopochodne i ich znaczenie w powstawaniu zmian skórnych u chorych na atopowe zapalenie skóry. In: Alergia Astma Immunologia 2001.
42.
Sybilski AJ, Raciborski F, Lipiec A, et al. Uczulenie na aeroalergeny u pacjentów z atopowym zapaleniem skóry. Badanie ECAP. Alerg Astma Immunol 2013; 18: 182-187.
43.
Turjanmaa K, Darsow U, Niggemann B, Rancé F, Vanto T, Werfel T. EAACI/GA2LEN position paper: present status of the atopy patch test. Allergy Eur J Allergy Clin Immunol 2006; 61: 1377-1384.
44.
Mitchell EB, Chapman MD, Pope FM, Crow J, Jouhal SS. Basophils in alergen-induced patch test sites in aopic dermatitis. Lancet 1982; 1: 127-130.
45.
Darsow U, Laifaoui J, Kerschenlohr K, et al. The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy 2004; 59: 1318-1325.
46.
Visitsunthorn N, Chatpornvorarux S, Pacharn P, Jirapongsananuruk O. Atopy patch test in children with atopic dermatitis. Ann Allergy Asthma Immunol 2016; 117: 668-673.
47.
Ayala F, Balato N, Lembo G, et al. A multicentre study of contact sensitization in children. Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali (GIRDCA). Contact Dermatitis 1992; 26: 307-310.
48.
Dickel H, Kuhlmann L, Bauer A, et al. Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000–2015: a retrospective multicentre study. J Eur Acad Dermatology Venereol 2020; 34: 2086-2095.
Share
RELATED ARTICLE
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
