REVIEW PAPER
The effect of intrauterine hypotrophy on the cardiovascular system of neonates
1
Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Zabrze, Poland
2
Department of Neonatology, Medical University of Silesia in Katowice, Specialist Hospital No. 2 in Bytom, Poland
3
Department of Gynaecology, Obstetrics, and Gynaecological Oncology, Medical University of Silesia in Katowice, Specialist Hospital No. 2 in Bytom, Poland
Submission date: 2019-01-26
Final revision date: 2019-04-27
Acceptance date: 2019-04-28
Publication date: 2019-06-28
Pediatr Pol 2019;94(3):193-197
KEYWORDS
TOPICS
ABSTRACT
Intrauterine hypotrophy is an important, dangerous, and increasingly common complication of pregnancy. It is also the most common factor identified in cases of stillbirth. Intrauterine growth restriction plays a significant role in short- and long-term outcome and is associated with brain damage and neurodevelopmental impairment. Perinatal asphyxia is observed in 50% of the population of growth-restricted infants, who are also more prone to early complications such as intraventricular haemorrhage, necrotising enterocolitis, persistent pulmonary hypertension, hypoglycaemia, or hypothermia. There are also long-term consequences of intrauterine growth retardation, projecting into adult life, such as increased risk of cardiovascular disease, endocrine disorders, renal dysfunction, or metabolic syndrome. These observations are consistent with Barker’s hypothesis, now referred to as the “developmental origins of health and disease”. This article is a review of the literature regarding early and long-term complications as well as cardiovascular risk in this group of patients.
REFERENCES (40)
2.
Smith CJ, Ryckman KK. Epigenetic and developmental influences on the risk of obesity, diabetes, and metabolic syndrome. Diabetes Metab Syndr Obes 2015; 8: 295-302.
3.
Berends LM, Dearden L, Tung YCL, et al. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia 2018; 61: 2225-2234.
4.
Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: 290-296.
5.
Cosmi E, Fanelli T, Visentin S, et al. Consequences in Infants That Were Intrauterine Growth Restricted. J Pregnancy 2011; 2011: 364-381.
6.
Lee ACC, Katz J, Blencowe H, et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob Health 2013; 1: 26-36.
7.
Podsiadło B, Caus I, Naworska B, et al. Hipotrofia płodu – przyczyny, sposoby prowadzenia ciąży i rozwiązanie w materiałach II Kliniki Położnictwa i Ginekologii Śląskiej Akademii Medycznej w Katowicach. Klin Perin Gin 2007; 43: 61-64.
8.
Savchev S, Figueras F, Sanz-Cortes M, et al. Evaluation of an Optimal Gestational Age Cut-Off for the Definition of Early- and Late-Onset Fetal Growth Restriction. Fetal Diagn Ther 2014; 36: 99-105.
9.
Figueras F, Caradeux J, Crispi F, et al. Diagnosis and surveillance of late-onset fetal growth restriction. Am J Obstet Gynecol 2018; 218: S790-S802.
10.
Garite TJ, Clark R, Thorp JA. Intrauterine growth restriction increases morbidity and mortality among premature neonates. Am J Obstet Gynecol 2004; 191: 481e7.
11.
Mitrovic L, Mikovic Z, Markovic MV, Mihailovic S. Impact of transient period of metabolic adaptation on perinatal asphyxia in neonates with intrauterine growth retardation. J Matern Fetal Neonatal Med 2017; 30: 2665-2670.
12.
Figueras F, Eixarch E, Meler E, et al. Small-for-gestational-age fetuses with normal umbilical artery Doppler have suboptimal perinatal and neurodevelopmental outcome. Eur J Obstet Gynecol Reprod Biol 2008; 136: 34-38.
13.
De Boo HA, Harding JE. The developmental origins of adult disease (Barker) hypothesis. Aust N Z J Obstet Gynaecol 2006; 46: 4-14.
14.
Barker DJP. Adult consequences of fetal growth restriction. Clin Obstet Gynecol 2006; 49: 270-283.
15.
Barker DJP. In utero programming of cardiovascular disease. Theriogenology 2000; 53: 555-574.
16.
Jones CT, Lafeber HN, Roebuck MM. Studies on the growth of the fetal guinea pig. Changes in plasma hormone concentration during normal and abnormal growth. J Dev Physiol 1984; 6: 461-472.
17.
Mohan R, Baumann DC, Alejandro EU. Fetal undernutrition, placental insufficiency and pancreatic β-cell development programming in utero. Am J Physiol Regul Integr Comp Physiol 2018; 315: R867-R878.
18.
Bertin E, Gangnerau MN, Bellon G, et al. Development of β-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy. Am J Physiol Regul Integr Comp Physiol 2002; 283: R623-R630.
19.
Jones CT, Lafeber HN, Rolph TP, Parer JT. Studies on the growth of the fetal guinea pig. The effects of nutritional manipulation on prenatal growth and plasma somatomedin activity and insulin-like growth factor concentrations. J Dev Physiol 1990; 13: 189-197.
20.
Anversa P, Kajstura J, Cheng W, et al. Insulin-like growth factor-l and myocyte growth: the danger of a dogma. Carciovasc Res 1996; 32: 484-495.
21.
Yzydorczyk C, Armengaud JB, Peyter AC, et al. Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches. J Dev Orig Health Dis 2017; 8: 448-464.
22.
Skilton MR, Evans N, Griffiths KA, et al. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 2005; 365: 1484-1486.
23.
Koklu E, Kurtoglu S, Akcakus M, et al. Increased aortic intima-media thickness is related to lipid profile in newborns with intrauterine growth restriction. Horm Res 2006; 65: 269-275.
24.
Koklu E, Ozturk MA, Kurtoglu S, et al. Aortic intima-media thickness, serum IGF-I, IGFBP-3, and leptin levels in intrauterine growth-restricted newborns of healthy mothers. Pediatr Res 2007; 62: 704-709.
25.
Baum M. Role of the kidney in the prenatal and early postnatal programming of hypertension. Am J Physiol Renal Physiol 2010; 298: F235-F247.
26.
Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1988; 1: 335-347.
27.
Gacka E, Więcek A. Rola zjawiska programowania płodowego w rozwoju chorób cywilizacyjnych. Nadciśn Tętn 2012; 16: 63-74.
28.
Crispi F, Miranda J, Gratacós E. Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease. Am J Obstet Gynecol 2018; 218: S869-S879.
29.
Crispi F, Crovetto F, Gratacos E. Intrauterine growth restriction and later cardiovascular function. Early Hum Dev 2018; 126: 23-27.
30.
Krzeszowski W, Janiak K, Kalinka J, et al. Modern methods of monitoring fetuses with intrauterine growth restriction. Ginekol Pol 2016; 87: 135-142.
31.
Crispi F, Hernandez-Andrade E, Pelsers MM, et al. Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol 2008; 199: 254.e1-8.
32.
Comas M, Crispi F, Cruz-Martinez R, et al. Usefulness of myocardial tissue Doppler vs. conventional echocardiography in the evaluation of cardiac dysfunction in early-onset intrauterine growth restriction. J Obstet Gynecol 2010; 203: 45.1-7.
33.
Zhu MY, Milligan N, Keating S, et al. The hemodynamics of late-onset intrauterine growth restriction by MRI. Am J Obstet Gynecol 2016; 214: 367.1-367.
34.
Fouzas S, Karatza AA, Davlouros PA, et al. Neonatal cardiac dysfunction in intrauterine growth restriction. Pediatr Res 2014; 75: 651-657.
35.
Tsyvian P, Malkin K, Artemieva O, Wladimiroff JW. Assessment of left ventricular filling in normally grown fetuses, growth-restricted fetuses and fetuses of diabetic mothers. Ultrasound Obstet Gynecol 1998; 12: 33-38.
36.
Sehgal A, Doctor T, Menahem S. Cardiac function and arterial biophysical properties in small for gestational age infants: postnatal manifestations of fetal programming. J Pediatr 2013; 163: 1296-1300.
37.
Crispi F, Bijnens B, Figueras F, et al. Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation 2010; 121: 2427-2436.
38.
Demicheva E, Crispi F. Long-Term Follow-Up of Intrauterine Growth Restriction: Cardiovascular Disorders. Fetal Diagn Ther 2014; 36: 143-153.
39.
Schipke J, Gonzalez-Tendero A, Cornejo L, et al. Experimentally induced intrauterine growth restriction in rabbits leads to differential remodelling of left versus right ventricular myocardial microstructure. Histochem Cell Biol 2017; 148: 557-567.
40.
Master JS, Zimanyi MA, Yin KV, et al. Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats. Clin Exp Pharmacol Physiol 2014; 41: 884-890.
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
