REVIEW PAPER
Physiological and pathological factors affecting the homeostasis of iron
Submission date: 2018-10-22
Final revision date: 2018-11-29
Acceptance date: 2018-11-29
Publication date: 2019-01-07
Pediatr Pol 2018;93(6):467-471
KEYWORDS
TOPICS
ABSTRACT
Iron plays a key role in many physiological body life processes, including determination of the correct erythropoiesis. Its lack leads to the development of anaemia, and excess iron can be toxic to the body. Iron homeostasis is supervised by the interaction of many proteins, of which hepcidin plays a very important role and whose modulators are transferrin, ferroportin, and erythropoietin. Important factors modifying iron homeostasis include hypoxia, anaemia, and vitamin concentration as well as acute and chronic inflammatory processes. Hepcidin as an acute phase protein can also be an important element in the diagnosis of infectious chronic diseases, especially as an anaemic determinant of these diseases. Its role in the pathomechanism of acute inflammatory states is not entirely clear.
REFERENCES (33)
1.
Filipczyk L, Król P, Wystrychowski A. Hepcydyna – hormon wątrobowy kontrolujący homeostazę żelaza. Forum Nefrol 2010; 3: 233-242.
2.
Beaumont C, Delaby C. Recycling iron in normal and pathological states. Semin Hematol 2009; 46: 328-338.
3.
Andrews NC. Forging a field: the golden age of iron biology. Blood 2008; 112: 219-230.
4.
Shayeghi M, Latunde-Dada GO, Oakhill J, et al. Identification of an intestinal heme transporter. Cell 2005; 122: 789-801.
5.
Zhang AS, Enns CA. Molecular mechanisms of normal iron homeostasis. Hematology Am Soc Hematol Educ Program 2009: 207-214.
7.
Kushner JP, Porter JP, Olivieri NF. Secondary iron overload. Hematology Am Soc Hematol Educ Program 2001: 47-61.
8.
Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem 2006; 281: 28494-28498.
9.
Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol Res 2011; 50: 1-9.
10.
Kossiva L, Gourgiotis DI, Tsentidis C, et al. Serum hepcidin and ferritin to iron ratio in evaluation of bacterial versus viral infection in children: a single-center study. Pediatr Infect Dis J 2012; 31: 795-798.
11.
Malyszko J. Hepcidin assays: ironing out some details. Clin J Am Soc Nephrol 2009; 4: 1015-1016.
12.
Park CH, Valore EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
13.
Andriopoulos B Jr, Corradini E, Xia Y, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 2009; 41: 482-487.
14.
Babitt JL, Huang FW, Wrighting FW, et al. Bone morphogenetic protein signalling by hemojuveline regulates hepcidin expression. Nat Genet 2006; 38: 531-539.
15.
Przybyszewska J, Żekanowska E. The role of hepcidin and haemojuveline in the pathogenesis of iron disorders in patients with severe malnutrition. Ann Agric Environ Med 2014; 21: 336-338.
16.
West AP, Bennett MJ, Sellers VM, et al. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with the transferring and the hereditary hemochromatosis protein HFE.
18.
Schmidt PJ, Toran PT, Gianetti AM, et al. The transferring receptor modulates HFE-dependent regulation of hepcidin expression. Cell Metab 2008; 7: 205-214.
19.
Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation. J Clin Invest 2002; 110: 1037-1044.
20.
Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-1023.
21.
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflamation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113: 1271-1276.
22.
Kemna E, Pickkers P, Nemeth E, et al. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005; 106: 1864-1866.
23.
Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest 2007; 117: 1755-1758.
24.
Singh B, Arora S, Agrawal P, et al. Hepcidin: a novel peptide hormone regulating iron metabolism. Clin Chim Acta 2011; 412: 823-830.
25.
Bacchetta J, Zaritsky JJ, Sea JL, et al. Suppression of iron-regulatory hepcidin by vitamin D. J Am Soc Nephrol 2014; 25: 564-572.
26.
Zughaier SM, Alvarez JA, Sloan JH, et al. The role of vitamin D in regulating the iron-hepcidine-ferroportin axis in monocytes. J Clin Transl Endocrinol 2014; 1: 19-25.
27.
Chiu PF, Ko SY, Chang CC. Vitamine C affects the expression of hepcidin and erythropoietin receptor in HepG2 cells. J Ren Nutr 2012; 22: 373-376.
28.
Citelli M., Bittencourt LL., da Silva SV, et al. Vitamina A modulates the expression of genes involved in iron bioavailability. Biol Trace Elem Res 2012; 149: 64-70.
29.
da Cunha MS, Siqueira EM, Trindade LS, et al. Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis. J Nutr Biochem 2014; 25: 1035-1044.
30.
Tsuchiya K, Nitta K. Hepcidin is a potential regulator of iron chronic kidney disease. Ther Apher Dial 2013; 17: 1-8.
31.
Taes YE, Wuyts B, Boelaert JR, et al. Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 2004; 42: 387-389.
32.
Zaritsky J, Young B, Wang H-J, et al. Hepcidin – a potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol 2009; 4: 1051-1056.
33.
Reichert CO, da Cunha J, Levy D, et al. Hepcidin: Homeostasis and diseases related to iron metabolism. Acta Haematol 2017; 137: 220-236.
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