Dystrophic epidermolysis bullosa is an inherited disease presenting with blistering of the skin and mucous membranes. The authors reviewed a case of siblings suffering from the disease. The first symptoms were noticed at the time of birth and epidermolysis bullosa was suspected. The lesions appear spontaneously or as a result of a trauma, even during everyday activities connected with getting dressed or hygiene. Except for skin lesions they also have symptoms from other organs, which is a challenge for the primary care pediatrician. Children also need the constant care of specialized team of doctors. The disease is a considerable burden on the life of whole families, therefore social support and psychological care are also necessary.