REVIEW PAPER
Congenital cataracts – a literature review
 
More details
Hide details
1
Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
 
2
Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland
 
 
Submission date: 2023-04-28
 
 
Final revision date: 2023-05-29
 
 
Acceptance date: 2023-05-30
 
 
Publication date: 2023-12-15
 
 
Corresponding author
Monika Nowak
Monika Nowak, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland
 
 
Pediatr Pol 2023;98(4):326-331
 
KEYWORDS
TOPICS
ABSTRACT
Congenital cataracts are clouding of the crystalline lens inside the eye, which is present at birth and leads to a decrease in vision. It is one of the three leading causes of blindness in children, responsible for up to 27.6% of cases. The etiology of congenital cataracts varies. The main causes include heredity, chromosomal aberrations, metabolic diseases, and intrauterine infections. Early diagnosis and treatment of congenital cataracts are essential in the prevention of irreversible loss of vision. The red reflex test is an excellent tool in the screening of congenital cataracts and should be performed on each newborn. Congenital cataract therapy differs from adult cataract therapy, being based primarily on early surgical intervention. Long-term post-operative rehabilitation is also an important part of care.
REFERENCES (55)
1.
Thompson J, Lakhani N. Cataracts. Prim Care 2015; 42: 409-423.
 
2.
Chan WH, Biswas S, Ashworth JL, et al. Congenital and infantile cataract: aetiology and management. Eur J Pediatr 2012; 171: 625-630.
 
3.
El Fkih L, Hmaied W, El Hif S, et al. Congenital cataract etiology. Tunis Med 2007; 85: 1025-1029. .
 
4.
Cassidy L, Taylor D. Congenital cataract and multisystem disorders. Eye 1999; 13: 464-473. .
 
5.
Aksay S, Bildirici I, Coşar CB, et al. Intrauterine cataract diagnosis and follow-up. Turk J Ophthalmol 2020; 50: 245-247.
 
6.
Qin Y, Zhong X, Wen H, et al. Prenatal diagnosis of congenital cataract: sonographic features and perinatal outcome in 41 cases. Ultraschall Med 2022; 43: e125-e134.
 
7.
Sheeladevi S, Lawrenson JG, Fielder AR, et al. Global prevalence of childhood cataract: a systematic review. Eye 2016; 30: 1160-1169.
 
8.
López Ulloa JA, Burn H, Beauregard AM. Causes of blindness and visual impairment in early childhood at a low vision service in Mexico City: a 15-year review. Ophthalmic Epidemiol 2021; 28: 420-427.
 
9.
Dash P, Rout JP, Panigrahi PK. Clinical patterns of congenital ocular anomalies in the pediatric age group (0 to 5 years) and its association with various demographic parameters. Indian J Ophthalmol 2022; 70: 944-947.
 
10.
Fei P, Liu Z, He L, et al. Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme – 1-year result. Acta Ophthalmol 2021; 99: e415-e422. .
 
11.
Cagini C, Tosi G, Stracci F, et al. Red reflex examination in neonates: evaluation of 3 years of screening. Int Ophthalmol 2017; 37: 1199-1204.
 
12.
Murhekar M, Verma S, Singh K, et al. Epidemiology of congenital rubella syndrome (CRS) in India, 2016-18, based on data from sentinel surveillance. PLoS Negl Trop Dis 2020; 14: e0007982.
 
13.
Fong AHC, Shum J, Ng ALK, et al. Prevalence of ocular abnormalities in adults with Down syndrome in Hong Kong. Br J Ophthalmol 2013; 97: 423-428.
 
14.
Reddy MA, Francis PJ, Berry V, et al. Molecular genetic basis of inherited cataract and associated phenotypes. Surv Ophthalmol 2004; 49: 300-315.
 
15.
Berry V, Georgiou M, Fujinami K, et al. Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches. Br J Ophthalmol 2020; 104: 1331-1337.
 
16.
Tătaru CI, Tătaru CP, Costache A, et al. Congenital cataract – clinical and morphological aspects. Rom J Morphol Embryol 2020; 61: 105-112.
 
17.
Messina-Baas O, Cuevas-Covarrubias SA. Inherited congenital cataract: a guide to suspect the genetic etiology in the cataract genesis. Mol Syndromol 2017; 8: 58-78.
 
18.
Shiels A, Hejtmancik JF. Mutations and mechanisms in congenital and age-related cataracts. Exp Eye Res 2017; 156: 95-102. .
 
19.
Musleh M, Ashworth J, Black G, et al. Improving diagnosis for congenital cataract by introducing NGS genetic testing. BMJ Qual Improv Rep 2016; 5: u211094.w4602.
 
20.
Bell SJ, Oluonye N, Harding P, et al. Congenital cataract: a guide to genetic and clinical management. Ther Adv Rare Dis 2020; 1: 2633004020938061.
 
21.
Augusteyn RC. Alpha-crystallin: a review of its structure and function. Clin Exp Optom 2004; 87: 356-366. .
 
22.
Berry V, Ionides A, Pontikos N, et al. The genetic landscape of crystallins in congenital cataract. Orphanet J Rare Dis 2020; 15: 333.
 
23.
Hejtmancik JF. Congenital cataracts and their molecular genetics. Semin Cell Dev Biol 2008; 19: 134-149. .
 
24.
Piatigorsky J. Molecular biology: recent studies on enzyme/crystallins and alpha-crystallin gene expression. Exp Eye Res 1990; 50: 725-728.
 
25.
Pichi F, Lembo A, Serafino M, et al. Genetics of congenital cataract. Dev Ophthalmol 2016; 57: 1-14.
 
26.
Taylan Şekeroğlu H, Utine GE. Congenital cataract and its genetics: the era of next-generation sequencing. Turk J Ophthalmol 2021; 51: 107-113.
 
27.
Shiels A, Bennett TM, Hejtmancik JF. Cat-Map: putting cataract on the map. Mol Vis 2010; 16: 2007-2015.
 
28.
Santana A, Waiswo M. The genetic and molecular basis of congenital cataract. Arq Bras Oftalmol 2011; 74: 136-142.
 
29.
Shiels A, Hejtmancik JF. Inherited cataracts: genetic mechanisms and pathways new and old. Exp Eye Res 2021; 209: 108662. .
 
30.
Poll-The BT, Maillette de Buy Wenniger-Prick CJ. The eye in metabolic diseases: clues to diagnosis. Eur J Paediatr Neurol 2011; 15: 197-204.
 
31.
Endres W, Shin YS. Cataract and metabolic disease. J Inherit Metab Dis 1990; 13: 509-516. .
 
32.
Savige J, Sheth S, Leys A, et al. Ocular features in Alport syndrome: pathogenesis and clinical significance. Clin J Am Soc Nephrol 2015; 10: 703-709.
 
33.
Zhu X, Du Y, He W, et al. Clinical features of congenital and developmental cataract in East China: a five-year retrospective review. Sci Rep 2017; 7: 4254.
 
34.
Self JE, Taylor R, Solebo AL, et al. Cataract management in children: a review of the literature and current practice across five large UK centres. Eye 2020; 34: 2197-2218.
 
35.
Gillespie RL, O’Sullivan J, Ashworth J, et al Personalized diagnosis and management of congenital cataract by next-generation sequencing. Ophthalmology 2014; 121: 2124-2137.
 
36.
Trivedi RH, Pandey SK. Pediatric Cataract Surgery Techniques, Complications, and Management. 2nd ed. Lippincott Williams & Wilkins, Philadelphia 2014.
 
37.
Katre D, Selukar K. The prevalence of cataract in children. Cureus 2022; 14: e30135.
 
38.
Grzybowski A. Okulistyka. Edra Urban & Partner, Wrocław 2020. .
 
39.
Magnusson G, Bizjajeva S, Haargaard B, et al. Congenital cataract screening in maternity wards is effective: evaluation of the Paediatric Cataract Register of Sweden. Acta Paediatrica 2013; 102: 263-267. .
 
40.
Adams GGW. The enduring value of newborn red reflex testing as a screening tool. JAMA Ophthalmol 2021; 139: 40-41.
 
41.
American Academy of Pediatrics, Section on Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, et al. Red reflex examination in neonates, infants, and children. Pediatrics 2008; 122: 1401-1404.
 
42.
How to test for the red reflex in a child. Community Eye Health 2014; 27: 36. .
 
43.
Haargaard B, Nyström A, Rosensvärd A, et al. The Pediatric Cataract Register (PECARE): analysis of age at detection of congenital cataract. Acta Ophthalmologica 2015; 93: 24-26.
 
44.
Bremond-Gignac D, Daruich A, Robert MP, et al. Recent developments in the management of congenital cataract. Ann Transl Med 2020; 8: 1545.
 
45.
Chen WR. [Reflections on surgical treatment of congenital cataract]. Zhonghua Yan Ke Za Zhi 2021; 57: 11-16.
 
46.
Lim ME, Buckley EG, Prakalapakorn SG. Update on congenital cataract surgery management. Curr Opin Ophthalmol 2017; 28: 87-92.
 
47.
Birch EE, Cheng C, Stager DR, et al. The critical period for surgical treatment of dense congenital bilateral cataracts. J AAPOS 2009; 13: 67-71.
 
48.
Lagrèze WA. Treatment of congenital and early childhood cataract. Ophthalmologe 2021; 118: 135-144.
 
49.
Mohammadpour M, Shaabani A, Sahraian A, et al. Updates on managements of pediatric cataract. J Curr Ophthalmol 2019; 31: 118-126.
 
50.
Yorston D. Surgery for Congenital Cataract. Community Eye Health 2004; 17: 23-25. .
 
51.
Khokhar SK, Pillay G, Dhull C, et al. Pediatric cataract. Indian J Ophthalmol 2017; 65: 1340-1349. .
 
52.
Estu D, Romadona Y, Djunaedi LA. Challenges and visual rehabilitation after pediatric cataract surgery. J Case Rep 2022; 11: 228-230.
 
53.
Weakley D, Cotsonis G, Wilson ME, et al. Anisometropia at age 5 years after unilateral intraocular lens implantation during infancy in the Infant Aphakia Treatment Study (IATS). Am J Ophthalmol 2017; 180: 1-7.
 
54.
Drews-Botsch CD, Hartmann EE, Celano M. Predictors of adherence to occlusion therapy three months after cataract extraction in the Infant Aphakia Treatment Study. J AAPOS 2012; 16: 150-155. .
 
55.
Kruger SJ, DuBois L, Becker ER, et al. Cost of intraocular lens vs. contact lens treatment after unilateral congenital cataract surgery in the IATS at age 5 years. Ophthalmology 2015; 122: 288-292. .
 
Journals System - logo
Scroll to top