ORIGINAL PAPER
A new insight into the management of high-grade vesicoureteral reflux
 
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1
Alexandria University, Alexandria, Egypt
 
2
Northern Ontario School of Medicine, TBRHSC, Thunder Bay, Canada
 
 
Submission date: 2022-03-09
 
 
Final revision date: 2022-06-01
 
 
Acceptance date: 2022-06-17
 
 
Publication date: 2022-12-30
 
 
Pediatr Pol 2022;97(4):308-310
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
High-grade vesicoureteral reflux (VUR) is a major dilemma to urologists, with no clear time for intervention in children without evidence of urinary tract infection. The aim of our study was to show our experience in managing high-grade VUR in children with high postvoiding residual.

Material and methods:
Our study included 24 children with high-grade reflux persistent while being on surveillance and continuous antibiotic prophylaxis. Besides radiological investigations, 24-hour urine output and postvoiding residual were our main clinical parameters to study.

Results:
All the children with high-grade reflux in our study were found to have polyuria and high postvoiding residual. Surgical correction was done through open surgical ureteral reimplantation combined with the use of vasopressin. Reduction cystoplasty was done for 2 children. One-year follow-up showed satisfactory outcomes in reducing bladder capacity and treating reflux.

Conclusions:
Children with high-grade VUR should be assessed for polyuria. The presence of polyuria should be an indication for early surgical management.
REFERENCES (14)
1.
Nordenström J, Sjöström S, Sillén U, Sixt R, Brandström P. The Swedish infant high-grade reflux trial: UTI and renal damage. J Pediatr Urol 2017; 13: 146-154.
 
2.
Tekgül S, Riedmiller H, Hoebeke P, et al. EAU guidelines on vesicoureteral reflux in children. Eur Urol 2012; 62: 534-542.
 
3.
Esposito C, Escolino M, Lopez M, et al. Surgical management of pediatric vesicoureteral reflux: a comparative study between endoscopic, laparoscopic, and open surgery. J Laparoendosc Adv Surg Tech A 2016; 26: 574-580.
 
4.
Guney D, Tiryaki TH. The prevalence of redo-ureteroneocystostomy and associated risk factors inpediatric vesicoureteral reflux patients treated with ureteroneocystostomy. Urol J 2019; 16: 72-77.
 
5.
Cakmak O, Tarhan H, Akarken I, et al. Can we predict vesicoureteral reflux resolution in patients with non-neurogenic lower urinary tract dysfunction?. Int J Urol 2019; 26: 638-642.
 
6.
Beksac AT, Koni A, Bozacı AC, Dogan HS, Tekgul S. Postvoidal residual urine is the most significant non-invasive diagnostic test to predict the treatment outcome in children with non-neurogenic lower urinary tract dysfunction. J Pediatr Urol 2016; 12: 215.e1-8.
 
7.
Abou Youssif TM, Fahmy A, Rashad H, Atta MA. The embedded nipple: an optimal technique for re-implantation of primary obstructed megaureter in children. Arab J Urol 2016; 14: 171-177.
 
8.
Koff SA, Gigax MR, Jayanthi VR. Nocturnal bladder emptying: a simple technique for reversing urinary tract deterioration in children with neurogenic bladder. J Urol 2005; 174: 1629-1632.
 
9.
Hale JM, Wood DN, Hoh IM, et al. Stabilization of renal deterioration caused by bladder volume dependent obstruction. J Urol 2009; 182: 1973-1977.
 
10.
Leslie SW, Sajjad H, Sharma S. Postobstructive Diuresis. In: StatPearls. Treasure Island (FL): StatPearls July 1, 2020.
 
11.
Roth JD, Lesier JD, Casey JT, et al. Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney. J Pediatr Urol 2018; 14: 557.e1-557.e6.
 
12.
Su W, Cao R, Zhang XY, Guan Y. Aquaporins in the kidney: physiology and pathophysiology. Am J Physiol Renal Physiol 2020; 318: F193-F203.
 
13.
Kortenoeven ML, Fenton RA. Renal aquaporins and water balance disorders. Biochim Biophys Acta 2014; 1840: 1533-1549.
 
14.
Naghizadeh S, Kefi A, Dogan HS, Burgu B, Akdogan B, Tekgul S. Effectiveness of oral desmopressin therapy in posterior urethral valve patients with polyuria and detection of factors affecting the therapy. Eur Urol 2005; 48: 819-825.
 
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